MISTLETOE (Viscum album var. coloratum) Growing on Carpinus laxiflora BL. Induces the Differentiation of Human Acute Promyeocytic Leukemia (HL-60) Cells
2004
Kim, S.C. (Cheju National University, Jeju, Republic of Korea) | Cho, H.Y. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea) | Park, S.Y. (Cheju National University, Jeju, Republic of Korea) | Hyoun, J.H. (Cheju National University, Jeju, Republic of Korea) | Lee, Y.J. (Cheju National University, Jeju, Republic of Korea) | Kang, J.H. (Cheju National University, Jeju, Republic of Korea) | Lee, Y.K. (Cheju National University, Jeju, Republic of Korea) | Park, D.B. (Cheju National University, Jeju, Republic of Korea) | Yoo, E.S. (Cheju National University, Jeju, Republic of Korea) | Kang, H.K. (Cheju National University, Jeju, Republic of Korea), E-mail: pharmkhk@cheju.ac.kr
The present study was undertaken to investigate the effects of mistletoe (Viscum album var. coloratum) growing on Carpinus laxiflora BL. on proliferation and differentiation of HL-60 acute promyelocytic leukemia cells. Aqueous extract and its (NH₄)₂SO₄ saturated fractions of the mistletoe exhibited potent anti-proliferation activity against HL-60 cells. Moreover, when HL-60 cells were treated with 0~30% and 30~70% (NH₄)₂SO₄ saturated fractions of the mistletoe, HL-60 expressed CD 66b or CD 14 cell surface antigens and showed activity to reduce nitroblue tetrazolium, indicating that mistletoe induces the differentiation of HL-60 into granulocytes or monocytes.
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