Inhibitory Activity of Plant Extracts against Prolyl Endopeptidase
2004
Kim, G.S. (National Institute of Crop Science, RDA, Suwon, Republic of Korea), E-mail: [email protected] | Lee, H.J. (Kyungpook National University, Daegu, Republic of Korea) | Lee, S.E. (National Institute of Crop Science, RDA, Suwon, Republic of Korea) | Kim, Y.M. (National Institute of Crop Science, RDA, Suwon, Republic of Korea) | Park, C.G. (National Institute of Crop Science, RDA, Suwon, Republic of Korea) | Seong, N.S (National Institute of Crop Science, RDA, Suwon, Republic of Korea) | Jeon, S.Y. (Kyungpook National University, Daegu, Republic of Korea) | Song, K.S. (Kyungpook National University, Daegu, Republic of Korea)
Prolyl endopeptidase (PEP) is proline-specific serine protease, cleaving peptied bonds on the biologically active neuropeptides such as substance P, vassopressin, and thyrotropin-releasing hormone and is, therefore, suggested to play inportant roles in learning and memory process. In this work, the inhibitory effect of plant extracts on PEP was investigated. Out of 200 plant extracts, Prunus mume, Pyrola japonica, Hypericum ascyron, Astibe chinensis var. typica, and Elaeagnus umbellata inhibited more than 90% of PEP activity at the concentration of 5 ppm.
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