Anti-inflammatory Effect of Patrinia villosa Extract on Proteinase-activated Receptor-2 Mediated Paw Edema
2004
Lim, J.P. (Woosuk University, Jeonju, Republic of Korea), E-mail: limjp@woosuk.ac.kr | Cui Xun (Woosuk University, Jeonju, Republic of Korea)
The root of Patrinia villosa Jussieu (Valerianaceae) has long been used for teatment of infectious diseases in Korea. In this study, the anti-inflammatory effect of the Patrinia villosa root water extract (PVWX) was investigated in proteinase-activated receptor-2 (PAR2)-mediated rat paw edema. Paw edema was induced by injection of trypsin or trans-cinnamoyl-LIGRLO-NH₂ (tc-NH₂) into hindpaw of rats. PVWX (10, 50, 100 and 200 mg/kg) was orally administered 1 h before the induction of inflammation.
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