Effect of Physostigmine and Procyclidine, as a Combinational Prophylactic Regimen for Organophosphate Poisoning on Learning and Memory Process in Rats
2004
Cho, S.O. (Chungbuk National University, Cheongju, Republic of Korea) | Park, W.K. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea) | Cho, Y. (Agency for Defense Development, Daejeon, Republic of Korea) | Lee, S.A. (Chungbuk National University, Cheongju, Republic of Korea) | Kim, H.K. (Chungbuk National University, Cheongju, Republic of Korea) | Kim, Y.B. (Chungbuk National University, Cheongju, Republic of Korea) | Seong, Y.H. (Chungbuk National University, Cheongju, Republic of Korea), E-mail: vepharm@chungbuk.ac.kr | Hur, G.H. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea) | Cheon, K.C. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea) | Kim, W.S. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea) | Ha, Y.C. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea) | Yeon, G.B. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea) | Kim, J.C. (Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea)
The effects of physostigmine and procyclidine, as a combinational prophylactic regimen for organophosphate poisoning, on learning and memory process were exaministering subcutaneously. Procyclidine at doses of 3 through 10 mg/kg produced significant impairment of learning and memory process in step-through passive avoidance test. However, this harmful effect of procyclidine (3 and 5 mg/kg) was reversed by simultaneous injection of physostigmine (0.1 mg/kg). Procyclidine at dises of 7 and 10 mg/kg produced reversible inhibition of learning and momory process in Morris water maze test.
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