Effects of Recombinant Human Erythropoietin Treatment in Male Cynomolgus Monkeys (Macaca fascicularis) (I): Hematological and Histopathological Changes
2005
Kim, C.Y. (Korea Institute of Toxicology, KRICT, Daejeon, Republic of Korea), E-mail: [email protected] | Kim, D.H. (CJ Corp., Ichon, Republic of Korea) | Kwon, M.S. (Kangwon National University, Chuncheon, Republic of Korea) | Yoon, S.J. (Korea Institute of Toxicology, KRICT, Daejeon, Republic of Korea) | Kim, Y.B. (Korea Institute of Toxicology, KRICT, Daejeon, Republic of Korea) | Ha, C.S. (Korea Institute of Toxicology, KRICT, Daejeon, Republic of Korea) | Han, S.S. (Korea Institute of Toxicology, KRICT, Daejeon, Republic of Korea)
We investigated effects of recombinant human erythropoietin (rHuEPO) on body weight organ weight, hematology, serum biochemistry, and histopathology in 6 male cynomolgus monkeys (Macaca fascicularis). Six monkeys, composed of treatment and control groups, were intravenously administered 3 times per week at doses of 0 and 2730 IU/ 0.1 ml/kg with rHuEPO for 4 weeks. rHuEPO treatment did not show any change in body weights for 4 weeks and caused an increase of organ weight in spleen, salivary gland, kidney, and liver.
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