Cytotoxic Isoquinoline Alkaloids from Chelidonium majus var. asiaticum
2005
Lee, J. (Gyeongsang National University, Jinju, Republic of Korea) | Shon, M.Y. (Jinju National University, Jinju, Republic of Korea) | Jang, D.S. (Korea Institute of Oriental Medicine, Daejeon, Republic of Korea) | Ha, T.J. (Yeongnam Agricultural Research Institute, NICS, RDA, Milyang, Republic of Korea) | Seo, E.K. (Ewha Womans University, Seoul, Republic of Korea) | Hwang, S.W. (Gyeongsang National University, Jinju, Republic of Korea) | Park, K.H. (Gyeongsang National University, Jinju, Republic of Korea) | Yang, M.S. (Gyeongsang National University, Jinju, Republic of Korea), E-mail: msyang@nongae.gsnu.ac.kr | Nam, S.H. (Jinju National University, Jinju, Republic of Korea)
Two known isoquinoline alkaloids, (+)-chelidonine (1) and (-)-stylopine (2), were isolated from CHCl₃- soluble fraction of whole plants of Chelidonium majus L. var. asiaticum, and their structures were identified by spectroscopic methods and X-ray crystallographic analysis. Two isolates (1 and 2) were examined for their in vitro cytotoxic activities against five human cancer cell lines including DU-145 (prostate), MCF (breast), A549 (lung), HePG2 (liver), and HT-29 (colon) by sulphorhodamine B (SRB) assay.
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