Genotoxicity and Mutagenicity of the Extracts of Morus alba L.
2005
Jin, H.J. (Kangwon National University, Chunchon, Republic of Korea), E-mail: [email protected] | Lee, H.Y. (Kangwon National University, Chunchon, Republic of Korea) | Kim, J.D. (Kangwon National University, Chunchon, Republic of Korea) | Heo, M.Y. (Kangwon National University, Chunchon, Republic of Korea) | Lee, J.H. (Kangwon National University, Chunchon, Republic of Korea)
This study was carried out to investigate the genotoxicity in comet and in vitro micronucleus assay and mutagenicity in Ames test of the extracts from leaves and stem of Morus alba L. The samples showed a very weak cytotoxicity on the NIH/3T3 cells by SRB assay. The cell viability of the extracts and fractions from leaves and stems of Morus alba L. was 80% over at 500 ㎍/㎖, and that of the chloroform fractions from leaves and stems showed lower than others. The genotoxicity at 250 ㎍/㎖ of 100% EtOH and water extrats on the NIH/3T3 cells in comet assay was about 40% compared to positive control, and most fractions from 100% EtOH extract of the leaves showed stronger genotoxicity than that of fractions from the stem.
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