Acute Toxicity Evaluation of Lemon Grass (Cymbopogon citratus) Essential Oil in Rats
2005
Shin, J.Y. (Chonnam National University, Gwangju, Republic of Korea) | Park, S.C. (Kyungpook National University, Daegu, Republic of Korea) | Kim, K.H. (Biomist Co., Namyangju, Republic of Korea) | Bae, C.S. (Chonnam National University, Gwangju, Republic of Korea) | Kim, S.H. (Chonnam National University, Gwangju, Republic of Korea) | Shin, D.H. (Chonnam National University, Gwangju, Republic of Korea) | Kim, J.C. (Chonnam National University, Gwangju, Republic of Korea), E-mail: toxkim@chonnam.ac.kr
The present study was conducted to determine the potential acute toxicity of lemon grass (Cymbopogon citratus) essential oil by a single oral dose in Sprague-Dawley rats. The test article was orally administered once by gavage to male and female rats at dose levels of 0, 2,500, 5,000 or 10,000 mg/kg body weight. Mortalities, clinical findings, and body weight changes were monitored for the 14-day period following the administration. At the end of 14-day observation period, all animals were sacrificed and complete gross postmortem and histopathological examinations were performed.
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