HPLC Chromatographic Methods for Simultaneous Determination of Pholcodine and Ephedrine HCI with Other Active Ingredients in Antitussive-Antihistamine Oral Liquid Formulations
2006
Abdallah, Rokia M. (Pharmacognosy Department, Faculty of pharmacy, University of Alexandria, Alexandria, Egypt), E-mail: rokiaa@yahoo.com.
A description of simple, isocratic and precise reversed phase HPLC methods is given for simultaneous quantification of pholcodine and ephedrine hydrochloride together with either carbinoxamine maleate or terfenadine in antitussive-antihistaminic oral pharmaceutical formulations. Separations were carried out on XTerra and symmetry shield C18 column (250×4.6 mm, 5μm). The used isocratic elution systems were either 0.02 M KH₂PO₄-acetonitrile in the ratio of 75 : 25 and pH adjusted to 7.70 with orthophosphoric acid or sodium hydroxide, for syrup (method A), or 0.02 octanesulphonic acid sodium salt solution-acetonitrile-acetic acid in the ratio of 75 : 25 : 0.5 for suspension (method B).
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