Enhanced Lovastatin Production by Solid State Fermentation of Monascus ruber
2005
Xu, Bao-Jun (Chungnam National University, Daejeon, Republic of Korea) | Wang, Qi-Jun (South China University of Technology, Guangzhou, China) | Jia, Xiao-Qin (Chungnam National University, Daejeon, Republic of Korea) | Sung, C.K. (Chungnam National University, Daejeon, Republic of Korea), E-mail: kchsung@cnu.ac.kr
The purpose of this study was to optimize the solid state cultivation of Monascus ruber on sterile rice. A single-level-multiple-factor and a single-factor-multiple-level experimental design were employed to determine the optimal medium constituents and to optimize carbon and nitrogen source concentrations for lovastatin production. Simultaneous quantitative analyses of the β-hydroxyacid form and β-hydroxylactone for of lovastatin were performed by the high performance liquid chromatography (HPLC) method with a UV photodiode-array (PDA) detector.
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