Isolation of Antioxidative Compound from Scutellaria baicalensis G.
2006
Kim, S.C. (KTnG Central Research Institute, Daejeon, Republic of Korea), E-mail: ginsapo@ktng.com | Ahn, K.S. (Korea United Pharm Inc., Yeongi, Republic of Korea) | Park, C.K. (KTnG Central Research Institute, Daejeon, Republic of Korea) | Jeon, B.S. (KTnG Central Research Institute, Daejeon, Republic of Korea) | Lee, J.T. (KTnG Central Research Institute, Daejeon, Republic of Korea) | Park, W.J. (Kongju National University, Kongju, Republic of Korea)
Root of Scutellaria baicalensis G. was extracted with methanol and water to give the yield of 30.0% in order to find the antioxidant substance. The extract was fractionated with diethyl ether, n-butanol and water to test the inhibitive activity against xanthine oxidase. Three fractions inhibited the activities of xanthine oxidase by 48.2%, 10.2% and 2.8%, respectively, at the amount of 0.1 ㎍. A component that exhibited strong inhibition of xanthine oxidase was isolated from diethyl ether fraction (SE Fr.) by silica gel column chromatography and HPLC, and then identified by ¹H-NMR, ∨13C-NMR and MS spectrophotometry.
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