CAGE, a Novel Cancer/Testis Antigen Gene, Promotes Cell Motility by Activation ERK and p38 MAPK and Downregulating ROS
2006
Shim, H.E. (Kangwon National University, Chuncheon, Republic of Korea) | Shim, E.S. (Kangwon National University, Chuncheon, Republic of Korea) | Lee, H.S. (Kangwon National University, Chuncheon, Republic of Korea) | Hahn, J.H. (Kangwon National University, Chuncheon, Republic of Korea) | Kang, D.M. (Korea Basic Science Institute, Chunchon Center, Chunchon, Republic of Korea) | Lee, Y.S. (Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea) | Jeoung, D.I. (Kangwon National University, Chuncheon, Republic of Korea), E-mail: jeoungd@kangwon.ac.kr
We previously identified a novel cancer/testis antigen gene CAGE by screening cDNA expression libraries of human testis and gastric cancer cell lines with sera of gastric cancer patients. CAGE is expressed in many cancers and cancer cell lines, but not in normal tissues apart from the testis. In the present study, we investigated its role in the motility of cells of two human cancer cell lines: HeLa and the human hepatic cancer cell line, SNU387. Induction of CAGE by tetracycline or transient transfection enhanced the migration and invasiveness of HeLa cells, but not the adhesiveness of either cell line.
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