Differential Effects of Two Period Genes on the Physiology and Proteomic Profiles of Mouse Anterior Tibialis Muscles
2006
Bae, K.H. (Yonsei University, Wonju, Republic of Korea), E-mail: kbae@yonsei.ac.kr | Lee, K.S. (Yonsei University, Wonju, Republic of Korea) | Seo, Y.U. (Yonsei University, Wonju, Republic of Korea) | Lee, H.S. (Yonsei University, Wonju, Republic of Korea) | Kim, D.Y. (Yonsei University, Wonju, Republic of Korea) | Choi, I.H. (Yonsei University, Wonju, Republic of Korea), E-mail: ichoi@yonsei.ac.kr
The molecular components that generate and maintain circadian rhythms of physiology and behavior in mammals are present both in the brain (suprachiasmatic nucleus; SCN) and in peripheral tissues. Examination of mice with targeted disruptions of either mPer1 or mPer2 has shown that these two genes have key roles in the SCN circadian clock. Here we show that loss of the clock gene mPer2 affects forced locomotor performance in mice without altering muscle contractility. A proteomic analysis revealed that the anterior tibialis muscles of the mPer2 knockout mice had higher levels of glycolytic enzymes such as triose phosphate isomerase and enolase than those of either the wild type or mPer1 knockout mice.
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