S-Adenosyl-L-Methionine Analogues to Enhance the Production of Actinorhodin
2006
Chong, Y.H. (Konkuk University, Seoul, Republic of Korea) | Young, J.M. (Konkuk University, Seoul, Republic of Korea) | Kim, J.Y. (Konkuk University, Seoul, Republic of Korea) | Lee, Y.K. (Konkuk University, Seoul, Republic of Korea) | Park, K.S. (Konkuk University, Seoul, Republic of Korea) | Cho, J.H. (Konkuk University, Seoul, Republic of Korea) | Kwon, H.J. (Myongji University, Yongin, Republic of Korea) | Suh, J.W. (Myongji University, Yongin, Republic of Korea) | Lim, Y.H. (Konkuk University, Seoul, Republic of Korea), E-mail: yoongho@konkuk.ac.kr
It is known that overexpression of S-adenosyl-L-methionine (SAM) synthetase or exogenous addition of SAM enhances the production of actinorhodin, one of pigmented antibiotics found from Streptomyces coelicolor. In order to discover a novel compound as a signal molecule to produce actinorhodin instead of SAM, several compounds were synthesized based on the relationships between structures of the SAM analogues and their actinorhodin productivities. Of these, a few compounds showed better productivities of actinorhodin than SAM.
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