Nitrogen Control in Corynebacterium glutamicum: Proteins, Mechanisms, Signals
2007
Burkovski, Andreas (Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany), E-mail: aburkov@biologie.uni-erlangen.de
In order to utilize different nitrogen sources and to survive in a situation of nitrogen limitation, microorganisms have developed sophisticated mechanisms to adapt their metabolism to a changing nitrogen supply. In this communication, the recent knowledge of nitrogen regulation in the amino acid producer Corynebacterium glutamicum is summarized. The core adaptations of C. glutamicum to nitrogen limitation on the level of transcription are controlled by the global regulator AmtR. Further components of the signal pathway are GlnK, a P∧Ⅱ-type signal transduction protein, and GlnD.
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