Synthesis and Biological Activity of Fungal Metabolite, 4-Hydroxy-3-(3'-Methyl-2'-Butenyl)-Benzoic Acid
2007
Kim, H.J. (Yonsei University, Seoul, Republic of Korea) | Kwon, H.J. (Yonsei University, Seoul, Republic of Korea), E-mail: kwonhj@yonsei.ac.kr
4-Hydroxy-3-(3'-methyl-2'-butenyl)-benzoic acid (HMBA) was previously isolated from Curvularia sp. KF119 as a cell-cycle inhibitor. However, the present study used a novel and practical synthetic method to prepare a large quantity of HMBA. The synthetic HMBA was found to inhibit the cell-cycle progression of HeLa cells with a comparable potency to the natural fungal metabolite. The inhibition of the cell-cycle progression by the synthetic HMBA involved both the activation of p21∨WAF1 and the inhibition of cyclin D1 expression in the cells.
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