Ethanol Induced Leucocytic and Hepatic DNA Strand Breaks Are Prevented by Styela clava and Styela plicata Supplementation in Male SD Rats
2007
Kim, J.M. (Kyungnam University, Masan, Republic of Korea) | Park, H.R. (Kyungnam University, Masan, Republic of Korea) | Lee, S.C. (Kyungnam University, Masan, Republic of Korea) | Park, E.J. (Kyungnam University, Masan, Republic of Korea), E-mail: pej@kyungnam.ac.kr
In this study, the ability of Styela clava or Styela plicata to reduce ethanol-induced hepatotoxicity and hepatic and leucocytic DNA damages was evaluated. Twenty four male SD rats were given 25% ethanol containing water (ad lib, p.o.) and divided into 3 groups; ethanol treated control group (EtOH), ethanol+3% S. clava (EtOH+SC), and ethanol+3% S. plicata (EtOH+SP). After 6 weeks, the supplementation of S. calva reduced the plasma ALT, ALP and LDH activities significantly (p less than 0.05), while S. plicata induced significant decrease in the plasma LDH activity only.
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