Cytotoxic Effects of Decursin from Angelica gigas Nakai in Human Cancer Cells
2007
Park, K.W. (Sunchon National University, Sunchon, Republic of Korea) | Choi, S.R. (Sunchon National University, Sunchon, Republic of Korea) | Shon, M.Y. (Gyeongsang National University, Jinju, Republic of Korea) | Jeong, I.Y. (Korea Atomic Energy Research Institute, Jeongeup, Republic of Korea) | Kang, K.S. (Busan College of Information Technology, Busan, Republic of Korea) | Lee, S.T. (Sunchon National University, Sunchon, Republic of Korea) | Shim, K.H. (Gyeongsang National University, Jinju, Republic of Korea) | Seo, K.I. (Sunchon National University, Sunchon, Republic of Korea), E-mail: [email protected]
Anticarcinogenic-active compound was isolated and purified from Angelica gigas Nakai. The compound was identified as decursin (C∧19H∧20O∧5; molecular weight 328) by mass, IR spectrophotometry, ¹H-NMR and ∨13C-NMR. The proliferation decreased in a dose dependant fashion in the MCF-7 cells treated with decursin for 24 hours over the concentration of 20 ㎍/mL. The IC∧50 value of the decursin treatment for 24 hours were 31.04, 33.60, 27,24, 20.45 ㎍/mL in the SW480, 293, HepG2 and MCF-7 cells, respectively.
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