Inhibitory Activity of Ethanol Extracts of Ailanthus altissima and Luteolin-7-glucoside on Phospholipase A₂ activity
2007
Hua, Jin Mei (Yeungnam University, Gyeongsan, Republic of Korea) | Hwang, N.K. (Yeungnam University, Gyeongsan, Republic of Korea) | Hong, T.G. (Yeungnam University, Gyeongsan, Republic of Korea) | Kim, Y.K. (Yeungnam University, Gyeongsan, Republic of Korea) | Chung, H.K. (Yeungnam University, Gyeongsan, Republic of Korea) | Yang, J.H. (Yeungnam University, Gyeongsan, Republic of Korea) | Quan, Zhejiu (Yeungnam University, Gyeongsan, Republic of Korea) | Bae, K.H. (Chungnam National University, Daejeon, Republic of Korea) | Thanh, Pham Ngoc (Chungnam National University, Daejeon, Republic of Korea) | Son, K.H. (Andong National University, Andong, Republic of Korea) | Kim, H.P. (Kangwon National University, Chuncheon, Republic of Korea) | Kang, S.S. (Seoul National University, Seoul, Republic of Korea) | Chang, H.W. (Yeungnam University, Gyeongsan, Republic of Korea), E-mail: [email protected]
In our continuing effort to investigate compounds having anti-inflammatory activity from natural products, Ailanthus altissima was examined. Among six compounds isolated from Ailanthus altissima, Luteolin-7-O-glucoside (L7G) along with ethanol extract of Ailnathus altissima (EAa) were chosen to determine their inhibitory activity on secretory recombinant phospholipase A₂s enzyme activity in vitro. As a results, EAa inhibited human recombinant sPLA₂-V (IC∧50 of about 100 ㎍/ml) and cPLA₂, (IC∧50 of about 59 ㎍/ml), while L7G showed strong inhibitory effect on sPLA₂-A, V and cPLA₂ with an IC∧50 value of approximately 40 μM, respectively.
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