Effect of Mutation in α-COP, A Subunit of the COPI Vesicle, on Cell Wall Biogenesis in Fungi
2007
Lee, H.H. (Chungnam National University, Daejeon, Republic of Korea) | Park, H.M. (Chungnam National University, Daejeon, Republic of Korea), E-mail: hmpark@cnu.ac.kr
The cell wall is essential for the survival and osmotic integrity of fungal cells. It is the framework to which biologically active proteins such as cell adhesion molecules and hydrolytic enzymes are attached or within which they act. Recently it was shown that mutations in α-COP, a subunit of COPI vesicle, is responsible for the thermo-sensitive osmo-fragile phenotype of fungi, such as Saccharomyces cerevisiae and Aspergillus nidulans, and suggested that α-COP may play a crucial role in translocation of protein(s) of the β-1,3-gulcan synthase complex and cell wall proteins, thus may contribute to the maintenance of cell wall integrity.
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