Protective effect of lectin from Synadenium carinatum on Leishmania amazonensis infection in BALB/c mice
2007
Afonso-Cardoso, Sandra R. (Universidade Federal de Uberlandia, MG, Brazil) | Rodrigues, Flavio H. (Universidade Federal de Uberlandia, MG, Brazil) | Gomes, Marcio A.B. (Universidade Federal de Uberlandia, MG, Brazil) | Silva, Adriano G. (Laboratorio de Imunologia Celular e Humoral do Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brazil) | Rocha, Ademir (Universidade Federal de Uberlandia, MG, Brazil) | Guimaraes, Aparecida H.B. (Universidade Federal de Uberlandia, MG, Brazil) | Candeloro, Ignes (Universidade Federal de Uberlandia, MG, Brazil) | Favoreto Jr., Silvio (Northwestern University Feinberg School of Medicine, Chicago, IL, USA) | Ferreira, Marcelo (Universidade Federal de Uberlandia, MG, Brazil) | De Souza, Maria A. (Universidade Federal de Uberlandia, MG, Brazil), E-mail: [email protected]
The protective effect of the Synadenium carinatum latex lectin (ScLL), and the possibility of using it as an adjuvant in murine model of vaccination against American cutaneous leishmaniasis, were evaluated. BALB/c mice were immunized with the lectin ScLL (10, 50, 100 ㎍/animal) separately or in association with the soluble Leishmania amazonensis antigen (SLA). After a challenge infection with 10∨6 promastigotes, the injury progression was monitored weekly by measuring the footpad swelling for 10 weeks.
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