Antiproliferative Effect of Silkworm Extract
2007
Lim, H.Y. (Hanyang University, Seoul, Republic of Korea) | Lim, Y.E. (HyeSung Hospital, Seoul, Republic of Korea) | Hong, S.W. (Konkuk University, Seoul, Republic of Korea) | Lee, C.H. (Hanyang University, Seoul, Republic of Korea) | Lim, Y.H. (Konkuk University, Seoul, Republic of Korea), E-mail: [email protected]
In normal cell growth, the balance between cellular proliferation and apoptosis is maintained; however, in the cancer cells, this balance gets out of control [Khosraviani et al., 1996]. Abnormal proliferation increases in the cancer cells, thereby inducing the tumor growth. Therefore, the induction of apoptosis could be important to the cancer chemotherapy. Apoptotic inducers are screened to discover anticancer drugs [fotedar et al., 1996]. While apoptosis preserves the cell membrane, necrosis destructs it, enabling the differentiation of the two systems based on their effects on the cell morphology [Darzynkiewicz et al., 1992]. A flow cytometry is used for the observation of apoptosis, and MTT assay for the observation of the antiproliferative effect of the cell growth.
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