Inhibition effects of extracts and its solvent fractions isolated from Limonium tetragonum of growth of human cancer cells
2008
Kong, C.S. (Korea Maritime University, Busan, Republic of Korea) | Um, Y.R. (Korea Maritime University, Busan, Republic of Korea) | Lee, J.I. (Korea Maritime University, Busan, Republic of Korea) | Kim, Y.A. (Korea Maritime University, Busan, Republic of Korea) | Lee, J.S. (Kunsan National University, Kunsan, Republic of Korea) | Seo, Y.W. (Korea Maritime University, Busan, Republic of Korea), E-mail: ywseo@hhu.ac.kr
In this study, crude extracts of the halophyte Limonium tetragonum and their solvent fractions were evaluated on anticancer activity in AGS and HT-29 human cancer cells using MTT assay. Each of the crude extracts (MeOH and CH₂Cl₂) of Limonium tetragonum showed a significant inhibitory effect on the growth of human cancer cells. The combined crude extracts of MeOH and CH₂Cl₂ were partitioned between CH₂Cl₂ and water. The organic layer was further partitioned between 85% aq. MeOH, n-hexane and n-BuOH fractions revealed very good inhibition effects on the growth of human cancer cells. These results suggest that we can isolate active compounds from Limonium tetragonum to show much more strong anticancer activity.
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