Cherry Tomatoes Ameliorate Scopolamine-induced Amnesia in Mice
2008
Choi, W.H. (Korea Food Research Institute, Seongnam, Republic of Korea) | Ahn, J.Y. (Korea Food Research Institute, Seongnam, Republic of Korea) | Kim, S.A. (Korea Food Research Institute, Seongnam, Republic of Korea) | Ha, T.Y. (Korea Food Research Institute, Seongnam, Republic of Korea), E-mail: tyhap@kfri.re.kr
Cherry tomatoes are rich in antioxidants, which may protect against neurodegeneration and consequent memory loss. This study was conducted to investigate the effect of cherry tomatoes on scopolamine-induced amnesia in mice. Male ICR mice (4 weeks old) were maintained for 4 weeks on a diet containing 10 or 20% tomato powder (TP), and then administered scopolamine (1 ㎎/㎏ body weight, i.p.) 45 min before memory testing. Passive avoidance and Morris water maze testing revealed that scopolamine-induced amnesia was significantly reduced in the TP groups compared to the non TP-received (control) group. Accordingly, acetylcholinesterase activities in the serum and brain of TP groups were lower than those in the control group. These findings suggest that cherry tomatoes may be useful for the prevention of neurodegenerative diseases such as amnesia and Alzheimer's disease.
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