Antimutagenic Effect and Cytotoxicity to Human Cancer Cell Lines of Colored Potato Extracts
2008
Park, Y.E. (National Institute of Highland Agriculture, RDA, Pyeongchang, Republic of Korea) | Jeong, J.C. (National Institute of Highland Agriculture, RDA, Pyeongchang, Republic of Korea) | Cho, H.M. (National Institute of Highland Agriculture, RDA, Pyeongchang, Republic of Korea) | Hwang, Y.S. (Kangwon National University, Samcheok, Republic of Korea) | Lee, H.J. (Kangwon National University, Samcheok, Republic of Korea) | Choi, S.S.N. (Kangwon National University, Samcheok, Republic of Korea) | Lee, S.J. (Kangwon National University, Samcheok, Republic of Korea) | Park, E.S. (Kangwon National University, Samcheok, Republic of Korea) | Ko, E.A. (Kangwon National University, Samcheok, Republic of Korea) | Kim, N.S. (Kangwon National University, Samcheok, Republic of Korea) | Lim, J.D. (Kangwon National University, Samcheok, Republic of Korea) | Choung, M.G. (Kangwon National University, Samcheok, Republic of Korea), E-mail: [email protected]
Colored potatoes are an excellent source of dietary polyphenols including anthocyanins. Generally, anthocyanins from fruits and vegetables exhibit anti-carcinogenesis and anti-cancer properties in vitro test. This experiment was conducted to know the effects of colored potato extracts contained anthocyanins on antimutagenic activity and anticancer activity to six human cancer cell lines containing LNCaP (androgen-dependent) prostate cancer cells. Extracts of three colored potatoes ('Hongyoung', 'Jayoung' and 'Jasim') and the white potato ('Superior') cultivars were used in this study. The extracts of three colored potatoes inhibited the mutagenicities induced by direct mutagen such as 4-nitro-quinoline-1-oxide (4-NQO) and another indirect mutagens of bezo(a)pyrene (BaP). Also, the extracts of 'Hoyoung' and 'Jayoung' showed higher antimutagenic activity than 'Jasim' and 'Superior' against to direct or indirect mutagen on both strains of TA98 and TA100. The activity of growth-inhibitory of extract of four potato cultivars were screened by SRB (sulphorhodamine B) method on diverse human cancer cells representing different types of cancers. Among the extract of four potato cultivars, the extract of 'Jasim' showed moderate inhibition on proliferation of LNCaP, ACHN and MOLT-4F cells and did not inhibit the proliferation of other cancer cells. On the other hand, extract of 'Superior' did not inhibit the proliferation of any tested cancer cell lines. However, the extracts of 'Hongyoung and Jayoung' inhibited the proliferation of cancer cells with GI∧50 values ranging from 2.5 to 30 ㎍/mL. On the basis of the GI∧50 values, it is clear that LNCaP cells were more sensitive to extracts of colored potato cultivars than other cancer cells. The extract of 'Jayoung' at 30 ㎍/mL were more active and inhibited cell proliferation, and induced apoptosis in LNCaP cells. This result revealed that the extracts of colored potatoes are expected to be good candidate for development into source of antimutagenic and anticancer agent.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by Korea Agricultural Science Digital Library
