Anti-inflammatory Effect Of Extracts from Cheongmoknosang (Morus alba L.) in Lipopolysaccharide-stimulated Raw Cells
2008
Cho, Y.J. (Kyungpook National University, Sangju, Republic of Korea), E-mail: [email protected] | An, B.J. (Daegu Haany University, Gyeongsan, Republic of Korea)
With extracts from Cheongmoknosang, anti-inflammatory effect was examined in LPS-stimulated Raw 264.7 cells. LPS (10 ng/ml) treatment increased the production of inflammatory cytokines, IL-1β, IL-6 and TNF-α but the ethanol extracts from Cheongmoknosang slightly decreased the production of TNF-α and also reduced the expression of iNOS and the production of COX-2. It seems that anti-inflammatory effects of ethanol extracts from Cheongmoknosang is partly due to the inhibition of iNOS and COX-2 expression by inhibiting nuclear translocation of NF-κB and AP-l in Raw 264.7 cells.
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