Antioxidant and Aldo-keto Reductase Family 1 B10 Inhibition Activities of Korean Local Plant Extracts
2009
Pan, C.H., Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute, Gangneung, Republic of Korea | Lee, J.Y., Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute, Gangneung, Republic of Korea | Song, D.G., Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute, Gangneung, Republic of Korea | Kim, J.H., Specialty Crops Experiment Station, Gangwondo Agricultural Research and Extension Services, Gangneung, Republic of Korea | Ahn, S.Y., Specialty Crops Experiment Station, Gangwondo Agricultural Research and Extension Services, Gangneung, Republic of Korea | Bae, D.S., Chungbuk National University, Cheongju, Republic of Korea | Kim, Y.H., Chungbuk National University, Cheongju, Republic of Korea | Lee, J.K., Chungbuk National University, Cheongju, Republic of Korea
Aldo-keto reductase family 1 B10 (AKR1B10) has been considered as a potential cancer therapeutic target. Ethanol extracts prepared from 82 Korean local plants were examined for their antioxidant activity and inhibitory effects on recombinant human AKR1B10 (rhAKR1B10) in vitro. 21 extracts showed more than 80% of ABTS radical scavenging activity at 100 ㎍/mL and 11 extracts inhibited more than 50% of rhAKR1B10 activity at 10 ㎍/mL. Especially, 9 extracts showed potent inhibition on rhAKR1B10 activity compared with positive control tetramethylene glutaric acid.
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