Antiproliferative Effect of Bacillus subtilis Fermented Soy Milk in AGS Human Gastric Adenocarcinoma Cells
2009
Seo, H.R., Pusan National University, Busan, Republic of Korea | Kim, J.Y., Pusan National University, Busan, Republic of Korea | Bae, G.H., Chunho Food Company, Busan, Republic of Korea | Park, K.Y., Pusan National University, Busan, Republic of Korea
Antiproliferative effects of soy milk fermented with Bacillus subtilis from chungkukjang was studied in AGS human gastric adenocarcinoma cells. The fermented soy milk by B. subtilis (B. subtilis-F-SM) exhibited 82% growth inhibitory effect at 2 mg/mL concentration, while non-fermented soy milk (Non-F-SM) showed 68%. B. subtilis-F-SM treated AGS cells induced more apoptotic bodies than the Non-F-SM treated cells. In mRNA expressions, B. subtilis-F-SM showed decreased expression of anti-apoptotic bcl-2 and increased expression of pro-apoptotic bax. The expressions of tumor suppressor genes of p53 and p21 were also increased. These results suggest that fermented soy milk by B. subtilis exhibited higher antiproliferative activities compared with non-fermented soy milk.
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