Effect of Red Pepper Seeds Powder on Antioxidative System and Oxidative Damage in Rats Fed High-FatㆍHigh-Cholesterol Diet
2009
Song, W.Y., International University of Korea, Jinju, Republic of Korea | Yang, J.A., Ulsan University, Ulsan, Republic of Korea | Ku, K.H., Korea Food Research Institute, Seongnam, Republic of Korea | Choi, J.H., International University of Korea, Jinju, Republic of Korea
The purpose of the present study was to effect of red pepper seeds powder on antioxidative defense system and oxidative damage in rats fed high fatㆍhigh cholesterol diet. Rats were divided into five experimental groups which are composed of normal diet group, high fatㆍhigh cholesterol diet group, high fatㆍhigh cholesterol diet with 5% red pepper seeds powder supplemented group (SA group), high fatㆍhigh cholesterol diet with 10% red pepper seeds powder supplemented group (SB group), and high fatㆍhigh cholesterol diet with 15% red pepper seeds powder supplemented group (SC group). Supplementation of red seed pepper groups (SA, SB, and SC groups) resulted in increased activities of hepatic glutathione peroxidase and superoxide dismutase. However, there was no significant difference in the activity of hepatic catalase among all experimental groups. Hepatic superoxide radical contents in microsome and mitochondria were significantly reduced in red pepper seeds powder supplemented groups. Hepatic hydrogen peroxide contents in mitochondria were significantly reduced 15% red pepper seeds powder supplemented group. Hepatic carbonyl values in microsome were significantly reduced in 10% and 15% red pepper seeds powder supplemented groups. Thiobarbituric acid reaction substance (TBARS) values in liver and plasma were reduced in red pepper seeds powder supplemented groups. These result suggest that red pepper seeds powder may reduce oxidative damage by the activation of antioxidative defense system in rats high fatㆍhigh cholesterol diets.
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