Selection and Mechanism of Anti-Obesity Agents from Natural Products Based on Anti-Angiogenesis
2009
Shin, J.H., Chonnam National University, Yeosu, Republic of Korea | Lee, J.H., Chonnam National University, Yeosu, Republic of Korea | Kang, K.W., Chonnam National University, Yeosu, Republic of Korea | Hwang, J.H., Chonnam National University, Yeosu, Republic of Korea | Han, K.H., Chonnam National University, Yeosu, Republic of Korea | Shin, T.S., Chonnam National University, Yeosu, Republic of Korea | Kim, M.Y., Chonnam National University, Yeosu, Republic of Korea | Kim, J.D., Chonnam National University, Yeosu, Republic of Korea
Anti-angiogenic mechanism was examined for anti-obesity agents with the extract of P.radix, P.semen, S.hebra and C.furctus through anti-cell adhesion effect and western blot. Cell adhesion molecules, VCAM-1 was supressed with the order of P.radix (0.2 ppm, 125%) greater than P.semen (0.5 ppm, 100%) greater than S.hebra (5.0 ppm, 114%) greater than C. furctus (5.0 ppm, 111.8%), ICAM-1 was inhibited by P.radix (0.25 ppm, 130%) greater than P.semen (0.5 ppm, 100%) greater than S.hebra (5.0 ppm, 138%) greater than C. furctus (5.0 ppm, 66.7%), E-Selectin was also supressed P.radix (0.25 ppm, 100%) greater than P.semen (1.0 ppm, 128%) greater than S.hebra (5.0 ppm, 120%) greater than C. furctus (5.0 ppm, 100.7%). And signal molecules, VE-cadherin was supressed by P.radix and S.hebra, β-catenin was inhibited by P.radix, and Akt was supressed all these 4 kinds of natural products. These P.radix, P.semen, S.hebra and C.furctus were showed the possibility of anti-obesity agents based on anti-angiogenesis.
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