Screening of Herbal Medicines from China and Vietnam with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (Ⅳ)
2009
Kim, J.M., Korea Institute of Oriental Medicine, Daejeon, Republic of Korea | Kim, Y.S., Korea Institute of Oriental Medicine, Daejeon, Republic of Korea | Kim, J.H., Kyungwon University, Seongnam, Republic of Korea | Yoo, J.L., Korea Institute of Oriental Medicine, Daejeon, Republic of Korea | Kim, J.S., Korea Institute of Oriental Medicine, Daejeon, Republic of Korea
Advanced glycation end products (AGEs) have been implicated in the development of diabetic complications. The AGEs inhibitors or cross-link breakers attenuate various functional and structural manifestations of diabetic complications. In this study, 64 herbal medicines from China and Vietnam have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, eight herbal medicines (IC∧50 less than 50 ㎍/ml) were found to have strong AGEs inhibitory activity compared with aminoguanidine (14 days, IC∧50=75.98 ㎍/ml; 28 days, IC∧50=88.27 ㎍/ml). Particularly, four herbal medicines, Buddleja officinalis (whole plant), Syzygium cuminii (leaf), Eugenia caryophyllate (seed), and Paeonia suffruticosa (root) showed more potent inhibitory activity (approximately 5-6 fold) than the positive control aminoguanidine.
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