Clinical Effects of Probiotics are Associated with Increased Transforming Growth Factor-β Responses in Infants with High-Risk Allergy
2011
Kim, J.Y., Seoul National University, Seoul, Republic of Korea | Choi, Y.O., Seoul National University, Seoul, Republic of Korea | Kwon, J.H., Sungkyunkwan University, Suwon, Republic of Korea | Ahn, K.M., Sungkyunkwan University, Suwon, Republic of Korea | Park, M.S., Anyang Science University, Anyang, Republic of Korea | Ji, G.E., Seoul National University, Seoul, Republic of Korea
We recently demonstrated that the administration of probiotics resulted in a significantly reduced occurrence of atopic dermatitis in infants with high allergic risk. Therefore, the underlying immunological effects that are associated with these apparent clinical benefits were determined. In a randomized, double-blind, placebo-controlled trial, the pregnant women and their infants with a family history of allergic diseases were supplemented with either probiotics (mixture of Bifidobacterium bifidum BGN4, Bifidobacterium lactis AD011, and Lactobacillus acidophilus AD031) or placebo once daily from 4-8 weeks before delivery to 6 months of infants' age. At 1 year of age, the levels of transforming growth factor (TGF)-β produced by peripheral blood monuclear cells from infants fed probiotics were significantly increased compared with those from infants fed placebo (p=0.042). Thus, reduction of atopic dermatitis prevalence with probiotics supplementation was associated with significant increases in the capacity of TGF-β responses.
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