Neuroprotection of Alpinia katsumadai Seed Extract against Neuronal Damage in the Ischemic Gerbil Hippocampus is Linked to Altered Brain-Derived Neurotrophic Factor
2011
Li, Hua, Kangwon National University, Chuncheon, Republic of Korea | Park, J.H., Kangwon National University, Chuncheon, Republic of Korea | Yan, B.C., Hallym University, Chuncheon, Republic of Korea | Yoo, K.Y., Gangneung-Wonju National University, Gangneung, Republic of Korea | Lee, C.H., Seoul National University, Seoul, Republic of Korea | Choi, J.H., Kangwon National University, Chuncheon, Republic of Korea | Hwang, I.K., Seoul National University, Seoul, Republic of Korea | Won, M.H., Kangwon National University, Chuncheon, Republic of Korea
The extract of Alpinia katsumadai, a member of the family Zingiberaceae, shows anti-inflammatory effects and antioxidant activity. We observed the neuroprotective effects of the extract from Alpinia katsumadai seed (EAKS) against ischemic damage in gerbils administered oral EAKS (25, and 50 mg/kg) once a day for 7 days before transient cerebral ischemia. In the 50 mg/kg EAKS-treated ischemia group, about 67% of neurons in the hippocampal CA1 region (CA1) survived after ischemia/reperfusion (I/R) based on cresyl violet staining. We observed that EAKS treatment significantly maintained brain-derived neurotrophic factor (BDNF) immunoreactivity in the ischemic CA1 region after I/R. In addition, protein levels of BDNF in the 50 mg/kg EAKS-treated ischemia group were much higher than those in the vehicle-treated ischemia group after I/R. These findings indicate that repeated supplementation of EAKS protects neurons from ischemic damage, such that BDNF is distinctively maintained in ischemic areas.
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