Tyrosinase Inhibitory Compounds Isolated from Persicaria tinctoria Flower
2011
Woo, Y.M., Konkuk University, Seoul, Republic of Korea | Kim, A.J., Konkuk University, Seoul, Republic of Korea | Kim, J.Y., Konkuk University, Seoul, Republic of Korea | Lee, C.H., Konkuk University, Seoul, Republic of Korea
To develop a new natural whitening agent, we investigated the tyrosinase inhibitory effects of Persicaria tinctoria Flower extracts (PTFE). PTFE showed inhibitory activity on mushroom tyrosinase with the IC∧50 values of 70.8±2.2 ㎍/mL. We purified two active compounds from PTFE by LH-20 column chromatography and prep-high performance liquid chromatography (HPLC) and identified as quercetin-3-O-rhamnoside (Q3R) and myricetin-3-O-rhamnoside (M3R) by ¹H-nuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry (LC-MS) analysis. Q3R and M3R showed tyrosinase inhibitory activities with the IC∧50 values of 47.0±0.1 ㎍/mL and 150.5±1.6 ㎍/mL, respectively. These results suggest that PTFE and its active compounds reduced melanin formation by the inhibition of tyrosinase activity. Thus, P. tinctoria flower extracts may be a candidate for cosmetic use.
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