The Protective Effects of the Ethyl Acetate Fraction and Flavonoids from Taraxacum coreanum against Oxidative Stress in Neuronal Cells Induced by Hydrogen Peroxide and Amyloid Beta
2013
Lee, A.Y., Pusan National University, Busan, Republic of Korea | Choi, J.M., Pusan National University, Busan, Republic of Korea | Lee, S.L., Chung-Ang University, Anseong, Republic of Korea | Kim, H.Y., Gyeongnam National University of Science and Technology, Jinju, Republic of Korea | Lee, S.H., Chung-Ang University, Anseong, Republic of Korea | Cho, E.J., Pusan National University, Busan, Republic of Korea
The protective role against oxidative stress under cellular system using C6 glioma cells was studied using the ethyl acetate (EtOAc) fraction, luteolin (1), and luteolin-7-glucoside (2) of Taraxacum coreanum. C6 glioma cells showed low cell viability and high generation of reactive oxygen species (ROS) by the treatment with generator of hydrogen peroxide (H2O2) and amyloid beta (Aβ25-35). However, the treatment of the EtOAc fraction attenuated the cellular oxidative stress, resulting in significant elevation of cell viability. In addition, the production of ROS formation was also decreased by the treatment of the EtOAc fraction. Compounds 1 and 2 were isolated from the EtOAc fraction, and the protective effect was evaluated. Compounds 1 and 2 led to the increase of cell viability and decrease of production of ROS against oxidative stress by H2O2 and Aβ25-35. The present study indicated that the EtOAc fraction, compounds 1 and 2 from T. coreanum demonstrated protective effects against oxidative stress, suggesting the preventive role against neurodegenerative diseases.
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