Antifungal chitinase against human pathogenic yeasts from Coprinellus congregatus
2014
Yoo, Y., Department of Biochemistry, Kangwon National University, Chunchon, Republic of Korea | Choi, H.T., Department of Biochemistry, Kangwon National University, Chunchon, Republic of Korea
The inky cap, Coprinellus congregatus, produces mushrooms which become autolyzed rapidly to generate black liquid droplets, in which no cell wall is detected by microscopy. A chitinase (Chi2) which is synthesized during the autolytic phase of C. congregatus inhibits the growths of Candida albicans and Cryptococcus neoformans up to 10% at the concentration of 10 §¶/ml, about 50% at concentration of 20 §¶/ml, and up to 95% at the concentration of 70 §¶/ml. Upon treatment these yeast cells are observed to be severely deformed, with the formation of large holes in the cell wall. The two yeast species show no growth inhibition at the concentration of 5 §¶/ml, which means the minimum inhibitory concentrations for both yeast species are 10 §¶/ml under these experimental conditions.
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