Acute Oral Toxicity Test of Chamaecyparis obtusa Essential Oil on ICR Mice
2018
Lim, C.W., Gyeongsang National University, Chinju, Republic of Korea | Son, S.E., Gyeongsang National University, Chinju, Republic of Korea | Lee, H.J., Gyeongsang National University, Chinju, Republic of Korea
The present study was carried out to investigate the acute oral toxicity of Chamaecyparis obtusa (C. obtusa) essential oil in ICR male and female mice. Acute oral treatment with C. obtusa essential oil did not reveal any sign of toxicity or mortality in treated mice. Mouse body weights were not affected after single oral administration of C. obtusa essential oil during the 14-day observation period. In the hematological and blood biochemical analysis, all parameters of the treated group with 2,000 mg/kg body weight of the essential oil were not significantly different those of the control group. Therefore, the lethal dose 50 of the essential oil was estimated to be greater than 2,000 mg/ kg body weight in mice, which indicated that the essential oil is non-toxic. In conclusion, this study suggests that C. obtusa essential oil orally safe ICR mice.
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