Effect of Euonymus alatus Extracts on Diabetes Related Markers in Pancreatic β-Cells and C57BL/Ksj-db/db Mice
2022
Kim, Y.R. | Kim, E.Y. | Lee, S.U. | Kim, Y.W. | Kim, Y.H.
Euonymus alatus (Thunb.) Sieb is known to have anti-cancer and anti-inflammatory effects. This study aimed to reveal the effect of the water extract and 70% ethanol (70% EtOH) extract of Euonymus alaltus in INS-1 cells (pancreatic beta cell line) and C57BL/Ksj-db/db mice (type 2 diabetes models). The water extract significantly increased the proliferation of INS-1 cells. However, the extracts of Euonymus alatus water and 70% EtOH had no effect on increasing the insulin secretion in INS-1 cells. In the animal model of type 2 diabetes, the extracts of Euonymus alatus water and 70% EtOH decreased the water intake and effectively increased the pancreatic insulin concentration. Furthermore, exposure to the 70% EtOH extract resulted in decreasing the plasma triglycerides. These data indicate that the extracts of Euonymus alatus water and 70% EtOH exert a partial anti-diabetic effect.
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