EVALUATION OF PHYTO CONSTITUENTS OF Caesalpinia sappan AGAINST SARS CoV-2 USING MOLECULAR DOCKING
2022
C M, Jaikanth | P, Raja | Jalantha P
unknown. SARS CoV-2 is a global pandemic threatening mankind and is causing great economic losses. Remedies are sought by eminent scientists throughout the world from various sources of available medicine. The search for the efficient drug candidate to combat the dreaded pandemic is still on. Caesalpinia sappan Linn. is a common medicinal herb having various medicinal properties like cytotoxic, antitumorigenic, anticoagulant, antioxidant, anti-inflammatory, antibacterial, antiviral, immunostimulant, and hepatoprotective properties. In this study, a few promising phyto constituents of C. sappan were chosen and their effects against the important disease-causing protein receptors of SARS CoV-2 were studied in silico. Phytoconstituents of Caesalpinia sappan (Caesalpin J, Deoxysappanone B, Methylepisappanol, Methylsappanol, Quercetin) expressed superior or equivalent binding affinity against the three chosen receptors of SARS CoV-2 namely spike glycoprotein, main protease, and RNA dependent RNA polymerase. Hence, necessary in vivo studies may be undertaken to evaluate the antiviral properties of C. sappan against SARS CoV-2.
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