Anti-inflammatory steroid (Prednisolone) and its effect on the adrenal gland
2000
Essawy, A.E. (Alexandria Univ. (Egypt). Dept. of Zoology) | Sakr, S.A. | Saleh, A.T. | El-Salmy, F.
Administration of an anti-inflammatory steroidal drug-Prednisolone- (0.85 mg/kg body weight, daily for 10 days) to adult toads Bufo tibamicus resulted in suppression of the function of the adrenal gland, as shown by a significant increase in the lipid droplets, autolysis of mitochondria and disorganization and degranulation of rER in the steroidogenic cells. Furthermore, chromaffin cells (catecholamines secreting cells), showed a marked decrease in the number of chromaffin granules and degenerative changes in the nuclei. These serious side effects should be taken into consideration when using this drug.
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