Analysis of metabolites of 4-methyl 2-sulfanilamido-oxazole (Sulfamethoxazole) excreted in the urine of goats
1998
Baig, M.I. (Government Coll., Faisalabad (Pakistan)) | Nawaz, M. | Iqbal, M.Z.
The urinary excretion and metabolism of 4-Methyl 2-sulfanilamido-oxazole (sulfamethoxazole) were determined in goats following intravenous injection of a single dose 50 mg/kg body weight. The percentage of intravenous dose of 4-Methyl 2-sulfanilamido-oxazole (sulfamethoxazole) excreted in the urine until 24 hours as total amine was 61.0 plus minus 5.2 percent, free amine 43.2 plus minus 4.6 percent and acetyl amine was 17.8 plus minus 1.2 percent. The mean plus minus SE values for relative percentage of Metabolite I identified as unchanged amine was 42.3% Metabolite II acetyl amine was 15.67 percent, Metabolite III hydroxy derivative 18.33 and as conjugated Metabolite were 23.33 percent. In goats, the urinary excretion and Metabolism of 4 Methyl 2-sulfanilamido-oxazole (sulfamethoxazole) revealed differences apprising as adjustment dosage regimen in the indigenous goats.
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