Some haematological changes produced in rabbits after intravenous inoculation of unilocular hydatid cyst fluid of sheep origin
1997
Anwar, Z. (Punjab Univ., Lahore (Pakistan). Dept. of Zoology) | Tanveer, A.
Experimental rabbits were inoculated with hydatid cyst fluid (HCF) of sheep origin to determine its toxicity by hematological changes in rabbits (Oryctolagus cuniculus). Five groups of animals were administered with crude low dose (CLD), filtered low dose (FLD), crude medium dose (CMD), filtered medium dose (FMD) and high dose (HD) of HCF and one control group given distilled water with same protocol. Blood samples were collected after every 14 days and different haematological analyses were made. An increasing trend of WBC count in all the groups was noted except for HD group in which decrease was noted. It was noted that RBC count shows initial increase in low dose groups but ultimately decreased resulting in anemic condition. Under both low dose treatments, PCV increased but decreased in medium and high dose groups. Haemoglobin (Hb) also decreased with the corresponding increase in the dose of HCF. MCV increased in low dose groups but decreased in medium dose and HD groups. There was general decrease in mean corpuscular haemoglobin and mean corpuscular haemoglobin content. ESR however, showed increasing trend with the increase in HCF dose. The interesting feature was the development of tolerance against HCF in almost all the cases. This is probably responsible for this disease to be of non dramatic type as for as symptoms are concerned in natural infection. It was further noted that the low dose groups reflected macrocytic hypochromic anemia where as medium dose and HD group reflected microcytic hypochromic anemia.
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