Clinical picture and therapeutic management of lead toxicosis insheep
2003
Zanch, H. | Pervez, K. | Sarwar, M.S. | Sindhu, S.,University ofVeterinary and Animal Sciences, Lahore (Pakistan). Dept. of ClinicalMedicine and Surgery
The project was aimed at evaluation of comparative therapeuticefficacy of two treatment regimes for the treatment of Iead poisoning insheep. For this purpose 20, two-months-old, lambs of Buchi breed wereused as experimental animals. Five animals were kept as healthy control,whereas the remaining 15 animals were given oral aqueous solution oflead acetate daily. The dose was started from 5 mg/kg bodyweight andwas increased gradually till it reached 100 mg/kg body weight by theend of 2nd month when clinical Toxicosis was observed. Clinical Findingsincluded diarrhea, hindquarter weakness and reduction of feed intake;accompanied by anemia and elevated blood lead levels up to 2.72 ppm.The 15 toxicated animals were divided into three groups A, Band Ccomprising of 5 animals each. Disodium calcium edentate, which was usedto treat animals of group A, resulted in 52.7% fall in blood lead level in5 days. A combination of disodium calcium edentate and thiaminehydrochloride was used to treat animals of group B, which showed 73.8percent fall in blood lead levels, Group C served as untreated control.Thus, combination therapy appears to be more effective for treatment oflead Toxicosis.
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