Impact of plasma protein glycation on lipid profile in diabetics with and without complications
2008
Saeed, T. (University of Agriculture, Faisalabad (Pakistan). Dept. of Chemistry) | Sheikh, M.A. (University of Agriculture, Faisalabad (Pakistan). Dept. of Chemistry)
Plasma protein glycation level and lipid profile were determined in normal group (G1) and in diabetic with and without complications groups (G2-G5). The level of glycation and glucose were high in diabetic with cardiovascular complications t6a other diabetic groups (G2-G5). Glucose via glycation end products has a central role in the pathogenesis of diabetic complications. The level of protein and high density lipoprotein (HDL-C) was lower in diabetics than normal. The level of cholesterol, low-density lipoprotein (LDL-C) and triglycerides were higher in diabetic with complication groups than diabetic without complications followed by normal. All the diabetic subjects with complications groups (G3-G5) had low level of protein but high level of glycation that contributed to the risk of diabetic complication. Cardiovascular patients had lower HDL- C level and high LDL-C level. Diabetes mellitus was accompanied by low HDL-C and high plasma triglyceride levels, which are major cardiovascular risk factor. The results indicated that the prevalence of diabetes increases with age. Females with relatively younger ages were found to be more prone to diabetes than males.
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