Kobalta katalizēta C‒H saites funkcionalizēšana: promocijas darba kopsavilkums
2022
LukasevicsLukašēvics, Lūkass Tomass, Lukass Tomass | Riga Technical University. Faculty of Materials Science and Applied Chemistry. Institute of Technology of Organic Chemistry
The aim of the Thesis is to develop novel, efficient and practical methodology for cobalt catalyzed C‒H bond functionalization. The following tasks were set: 1. Obtain amino acid and amino alcohol derivatives, which could be employed as substrates for C‒H bond functionalization reaction. Phenylglycinol and phenylalanine as model substrates were chosen (Fig. 3). 2. Explore the literature and select appropriate reagents that could be used for C‒H bond functionalization reactions. Perform optimization of reaction conditions, investigate the substrate scope. As a result of the Thesis, four novel C‒H bond functionalization methods of amino acid and amino alcohol derivatives were developed: 1. Cobalt catalyzed C‒H bond alkenylation of phenylglycinol derivatives. 2. Cobalt catalyzed C‒H bond carbonylation of phenylglycinol derivatives. 3. Cobalt catalyzed C‒H bond carbonylation of phenylalanine derivatives. 4. Cobalt catalyzed C‒H bond imination of phenylalanine derivatives. The Thesis is a collection of scientific publications on the cobalt-catalyzed C‒H bond alkenylation, carbonylation, and imination of phenylglycinol and phenylalanine derivatives as well as derivatization options of the obtained products.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by Fundamental Library of Latvia University of Life Sciences and Technologies
