Mapping quantitative trait loci for feed efficiency in mice - a preliminary analysis
2001
Hebart, M. | Bottema, C. | Pitchford, W. | Neville Jepson, | Conference of the Association for the Advancement of Animal Breeding & Genetics (14th : 2001 : Queenstown, New Zealand)
Mice from high and low feed efficiency selection lines were used in an F₂ mapping design. The mouse lines differed in feed intake by approximately 25% with only small differences in growth and body composition. One hundred and twenty progeny from 2 F₁ sires were selectively genotyped. A genome scan was done using 80 microsatellite markers evenly spaced every 20cM throughout the genome. A preliminary analysis using an analysis of variance resulted in the following 16 putative quantitative trait loci (QTL) (F Prob<0.01): three for net feed intake, one for daily feed intake, four for body fat %, three for average daily gain and five for metabolic mid-weight. A QTL affecting fat and weight mapped to the same region (chromosome 13) as other mouse studies.
Show more [+] Less [-]M.L. Fenton, C.D.K. Bottema, and W.S. Pitchford
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