Detection of natural bioantimutagens by bacterial short-term tests.
1994
Stevic T. | Vukovic Gacic B. | Knezevic Vukcevic J. | Jankov R.M. | Simic D.
Antimutagenic activity of CO2 reextract of the cultivated sage containing terpenoid fraction, detected in Escherichia coli repair proficient strain, was tested using Salmonella typhimurium / microsome assay (Ames test). There was no effect on spontaneous and UV-induced mutations in TA98 strain. The reduction of UV-induced mutation frequency was observed when tested with TA100 strain with metabolic activation. Possible reasons for the descrepancy between results obtained with Escherichia coli and Salmonella typhimurium test systems are described.
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