Process for the preparation of 2-alkyl-6-methyl-N- (1'-methoxy-2'-propyl)-aniline and a process for the preparation of their chloracetanilides.
1996
Riehan R.B. | Binningan P.F. | Radimenski P.
A process for the preparation of 2-alkyl-6-methyl-N (1'-methoxy-2'-propyl)- aniline by catalytic reductive alkylation wherein at least one mole equivalent of methoxyacetone is reacted with one mole equuivalent of 2-alkyl-6-methyl-aniline in a liquid medium without an additional solvent, in the presence of a platinized carbon catalyst and hydrogen and in the presence of an acid cocatalyst under a hydrogen pressure of between 2 x 10 to the 5th power and 1 x 10 to the 6th power Pa at temperature between 20 deg C and 80 deg C, characterized in that the reaction mixture contains water from the beginning of the reaction and after the hydrogenation, base is added, the reaction mixture is filtered to separate the catalyst and the title compound recovered from the filtrate. The process is particularly useful for the preparation of N-substituted chlorace familide herbicides.
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