Immunocytochemical and ultrastructural characteristics of pancreatic B-cells in rats treated with furfural
2003
Cekic, S. (University of Nis, Nis (Serbia and Montenegro). Faculty of Medicine, Institute of Physiology) | Filipovic, M. | Nesic, M. | Brankovic, S. | Ciric, M. | Katic, K. | Kamenov, S. | Dimitrijevic, O.
On the basis of the results obtained by the study, a conclusion may be drawn that furfural reduces the synthesis and deposition of insulin in endocrine B-cells of the pancreas. Furfural induces compensatory, non-significant hyperplasia of the B-cells as well as their nesidioblastosis, i.e., formation of the insula in the exocrine segment of the pancreas. The ultrastructural finding suggests a toxic effect of furfural upon B-cells. Degree of functional and ultrastructural damage to the examined cells correlates with progressive elevation of furfural dosage and the experiment duration.
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