The effect of ergosinine and dihydroergosine on intestinal motility in vivo and in vitro
1983
Radulovic, S. (Medical faculty, Beograd (Yugoslavia)) | Djordjevic, N. | Kazic, T.
In the in vivo experiments (rat) ergozin (ESNN) and dihidroergozin (DHESN) were used in 0,5, 1 and 2 mg/kg doses intraperitonally. It has been found that they slow down the transport of barium through the small intestine as opposed to dihydroergotamine (DHE) which, applied in the same doses excellerates the function. In the experiments in vitro (rabbit) ESNN and DHESN were gently stimulating spontanious pendular activity while used in small concentrations from 1-10 microgram/ml. In greater concentrations (10-50 microgram/ml) they inhibited the pendular movements. In this respect, the ESNN and DHESN were more active than DHE, Finally, ESNN and DHESN used in 10 microgram/ml concentration antagonized the relation of the bowles of the rabbit caused by noradrenalin and that was more efficient than DHE. The conclusion is that ESNN and DHESN affect the transport of solid matter through the small intestine in a different way than DHE which was shown in the experiments in vivo. In the experiments in vitro ESNN and DHESN showed a greater activity than DHE both as noradrenalin antagonists and as spontaneous pendular activity inhibitors.
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